What (Hydroxy)chloroquine Does To The Body…


….
Date: May 24, 2020

01) What (Hydroxy)chloroquine Does To The Body


“These cases are patients who I, or my colleagues have seen. They are de-identified and many instances have been presented in more depth in an academic setting. These videos are not individual medical advice and are for general educational purposes only. I do not give medical advice over the internet, see your own physician in person for that.

References:
[0] Treatment of Severe Chloroquine Poisoning. New England Journal Of Medicine 1988; 318:1-6.

[1] Hydroxychloroquine is much less active than chloroquine against chloroquine-resistant Plasmodium falciparum, in agreement with its physicochemical properties. J Antimicrob Chemother. 2003;52(2):188.

[2] Antimalarial toxicity: a review. https://pubmed.ncbi.nlm.nih.gov/14720085/?from_single_result=14720085&expanded_search_query=14720085

[3] Single IV delivery of chloroquine in the treatment of falciparum malaria: toxicity and immediate therapeutic effects in 110 cases. Am J Trop Med Hyg. 1950;30(4):503.

[4] Taking the “idio” out of “idiosyncratic”: predicting torsades de pointes. Pacing Clin Electrophysiol. 1998;21(5):1029.

[5] The IKr drug response is modulated by KCR1 in transfected cardiac and noncardiac cell lines. FASEB J. 2003;17(15):2263.

[6] Extracellular potassium modulation of drug block of IKr. Implications for torsade de pointes and reverse use-dependence. Circulation. 1996;93(3):407.

[7] Erythromycin blocks the rapid component of the delayed rectifier potassium current and lengthens repolarization of guinea pig ventricular myocytes. Circulation. 1995;91(12):3010.

[8] The mechanism of toxicity from quinidine and a method of resuscitation: an experimental study . J Clin Invest 1925; 1:497–517.

[9] Chloroquine toxicity. Br J Clin Pharmacol 1983; 15:502–3.

[10] Chloroquine intoxication: two case reports . Forensic Sci Int 1978; 11:177–9.

[11] Experimental assessment of the protecting activity of diazepam on the acute toxicity of chloroquine . J Toxicol Clin Toxicol 1983; 20:271–9.

[12] Treatment of chloroquine poisoning with diazepam: preliminary results of an experimental study. Intensive Care Med 1986.

Chubbyemu COVID-19 Playlist:
https://www.youtube.com/playlist?list=PL26HeTCO57qcOqYV6-5ZB9xleo_PaHxi4

….

CNBC Host MELTS DOWN When Biden Proposes Tax Hikes…


Date: May 23, 2020

01) CNBC Host MELTS DOWN When Biden Proposes Tax Hikes


“Joe Biden says he’ll roll back tax cuts for the wealthy and CNBC hosts lose it.

“Former Vice President Joe Biden on Friday said that he would not increase taxes on those making less than $400,000 annually.

“Nobody making under 400,000 bucks would have their taxes raised. Period. Bingo,” the presumptive Democratic presidential nominee said in an interview with CNBC.

Biden has floated a number of tax proposals during his campaign, largely targeted at raising taxes on wealthy individuals and businesses.

Citation:
https://thehill.com/policy/finance/499138-biden-pledges-not-to-raise-taxes-on-those-making-under-400000

Wow…Joe said something modestly good for once…

===